Abstract:
ardostachys jatamansi roots were extracted with water(50%) & ethanol(50%) and analyzed for its anti-parkinsonism effect by measuring various neurological and behavioral parameters at the test dose of 250mg/kg and 500mg/kg body wt. Haloperidol 1mg/kg body weight was administered i.p in order to induce Parkinsonism. Parkinsonism caused by depletion of dopamine level in substansia nigra. Hydro-alcoholic root extract of ardostachys jatamansi reversed the haloperidol induced Parkinsonism significantly (p<0.01), when compared to drugs, i.e. combination of L-dopa & Carbidopa (100mg+25mg/kg). From the above studies it could be predict that the symptoms of Parkinsonism may be due to alteration in dopaminergic system, which play important role in the protection from Parkinsonism. The levels altered by haloperidol were restored significantly by the administration of Hydro-alcoholic root extract of ardostachys jatamansi.The result of the study implies that ardostachys jatamansi is a potent source to protect the brain from dopamine depletion level.
