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Evaluation of toxicological and antioxidant potential of Nardostachys jatamansi in reversing haloperidol-induced catalepsy in rats

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dc.contributor.author Rasheed, A S
dc.contributor.author Venkataraman, S
dc.contributor.author Jayaveera, K N
dc.contributor.author Fazil, A Mohammed
dc.contributor.author Janapati, Yasodha Krishna
dc.contributor.author Aleem, M A
dc.contributor.author Mohammed, M
dc.contributor.author Khaja, Z
dc.contributor.author Ushasri, B
dc.contributor.author Pradeep, H A
dc.contributor.author Ibrahim, M
dc.date.accessioned 2020-01-06T06:39:03Z
dc.date.available 2020-01-06T06:39:03Z
dc.date.issued 2010
dc.identifier.uri http://erepo.usiu.ac.ke/11732/5166
dc.description Journal Article en_US
dc.description.abstract n aqueous root extract from Nardostachys jatamansi was investigated for its antioxidant and anticataleptic effects in the haloperidol-induced catalepsy rat model of the disease by measuring various behavioral and biochemical parameters. Catalepsy was induced by administration of haloperidol (1 mg/kg, ip) in male albino rats. A significant (P 0.01) reduction in the cataleptic scores were observed in all the drug-treated groups as compared to the haloperidol-treated group; with maximum reduction observed in the Nardostachys jatamansi(250 and 500 mg/kg body weight) administered group. To estimate biochemical parameters: the generation of thiobarbituric acid reactive substances (TBARS); reduced glutathione (GSH) content and glutathione-dependent enzymes; catalase; and superoxide dismutase (SOD), in the brain were assessed. Haloperidol administration increased generation of TBARS and signifi-cantly reduced GSH, which were restored to near normal level with the Nardostachys jatamansitreatment. Catalase and SOD levels were also increased to normal levels, having been reduced significantly by haloperidol administration. Our findings of behavioral studies and biochemical estimations show that Nardostachys jatamansi reversed the haloperidol-induced catalepsy in rats. We conclude that the antioxidant potential has contributed to the reduction in the oxidative stress and catalepsy induced by haloperidol administration. en_US
dc.publisher International Journal of General Medicine en_US
dc.subject Nardostachys jatamansi, antioxidant, toxicological, haloperidol and catalepsy en_US
dc.title Evaluation of toxicological and antioxidant potential of Nardostachys jatamansi in reversing haloperidol-induced catalepsy in rats en_US
dc.type Article en_US


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