The Effects of Selected Kenyan Herbal Formulations on Glucose, Lipid Levels and Hepatic Function in Alloxan Induced Diabetic Rats

Abstract

Polyherbal formulations used for management of diabetes in Kenya lack studies to determine their efficacy or safety. To evaluate the efficacy and safety of two anti-diabetic polyherbal formulations (LUC and MUI). Herbs were collected, dried and formulated. Formulations were evaluated using grouped alloxan induced wistar rats. Effects were compared to conventional drugs; pioglitazone (3mg/kg bw), glibenclamide (100 mg/kg bw), metformin (100 mg/kg bw) and normal control group. Each group received an individual drug/water once daily orally for fourteen days. Blood glucose levels were evaluated every seven days using a glucometer. Liver function tests and lipid profile were measured on day 14. The data was expressed in mean ± SEM. Analysis was by ANOVA and post hoc multicomparison Turkey test (p < 0.05). No mortalities reported. Both herbal preparations had hypoglycemic effects. LUC was more potent. MUI increased all lipid levels. LUC caused intestinal gas distention on gross examination. The herbal formulations were hypoglycemic at the tested doses.