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Cryptosporidiosis in HIV/AIDS Patients in Kenya: Clinical Features, Epidemiology, Molecular Characterization and Antibody Responses

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dc.contributor.author Wanyiri, Jane W.
dc.contributor.author Kanyi, Henry
dc.contributor.author Maina, Samuel
dc.contributor.author Wang, David E.
dc.contributor.author Steen, Aaron
dc.contributor.author Ngugi, Paul
dc.contributor.author Kamau, Timothy
dc.contributor.author Waithera, Tabitha
dc.contributor.author O’Connor, Roberta
dc.contributor.author Gachuhi, Kimani
dc.contributor.author Wamae, C.N.
dc.contributor.author Mwamburi, Mkaya
dc.contributor.author Ward, Honorine D.
dc.date.accessioned 2018-05-17T11:06:08Z
dc.date.available 2018-05-17T11:06:08Z
dc.date.issued 2014
dc.identifier.uri http://erepo.usiu.ac.ke/11732/3842
dc.description Journal Article en_US
dc.description.abstract We investigated the epidemiological and clinical features of cryptosporidiosis, the molecular characteristics of infecting species and serum antibody responses to three Cryptosporidium-specific antigens in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients in Kenya. Cryptosporidium was the most prevalent enteric pathogen and was identified in 56 of 164 (34%) of HIV/AIDS patients, including 25 of 70 (36%) with diarrhea and 31 of 94 (33%) without diarrhea. Diarrhea in patients exclusively infected with Cryptosporidium was significantly associated with the number of children per household, contact with animals, and water treatment. Cryptosporidium hominis was the most prevalent species and the most prevalent subtype family was Ib. Patients without diarrhea had significantly higher serum IgG levels to Chgp15, Chgp40 and Cp23, and higher fecal IgA levels to Chgp15 and Chgp40 than those with diarrhea suggesting that antibody responses to these antigens may be associated with protection from diarrhea and supporting further investigation of these antigens as vaccine candidates. en_US
dc.language.iso en en_US
dc.publisher The American Society of Tropical Medicine and Hygiene en_US
dc.relation.ispartofseries Am. J. Trop. Med. Hyg., 91(2), 2014, pp. 319–328;
dc.subject Cryptosporidiosis en_US
dc.subject HIV/AIDS Patients en_US
dc.subject Kenya en_US
dc.subject Clinical Features en_US
dc.subject Epidemiology en_US
dc.subject Molecular Characterization en_US
dc.subject Antibody Responses en_US
dc.title Cryptosporidiosis in HIV/AIDS Patients in Kenya: Clinical Features, Epidemiology, Molecular Characterization and Antibody Responses en_US
dc.type Article en_US


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