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Hepatoprotective Activity of Holostemma ada Kodien shcult, Extract against Paracetamol Induced Hepatic Damage in Rats

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dc.contributor.author Sunil, Junapudi
dc.contributor.author Janapati, Yasodha Krishna
dc.contributor.author Bramhachari, Pallaval Veera
dc.date.accessioned 2020-01-06T09:32:20Z
dc.date.available 2020-01-06T09:32:20Z
dc.date.issued 2015
dc.identifier.uri http://erepo.usiu.ac.ke/11732/5171
dc.description Journal Article en_US
dc.description.abstract Aim: To study the hepatoprotective activity of alcoholic extract of Holostemma ada Kodien Shcult against paracetamol (PCM) induced liver damage in rats. Place and Duration of Study: Department of pharmaceutical chemistry and department of pharmacology Geethanjali College of Pharmacy, Cherryal, Keesara, Ranga Reddy District, Andhra Pradesh, India during June 2012 and Jan 2014. Methods: Hepatotoxicity was induced by paracetamol (PCM) and various biochemical parameters were assessed to confirm the induced degrees of hepatoprotoxicity. The various extracts were tested on animals and various biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) and total serum bilirubin (SB) were investigated the hepatoprotective activity was also confirmed by histopathological studies of normal and hepatodamage and post treatment studies with the extract. The Results: Pre-treatment of the rats with alcoholic extract prior to paracetamol (PCM) administration caused a significant reduction in the values of AST, ALT, ALP and SB (p<0.01) approximately comparable to the hepatoprotective of standard drug was silymarin and confirmed by histopathological examination of the liver tissue of control and treated animals. Conclusion: From the results it can be concluded that Holostemma ada Kodien Shcult possesses the hepatoprotective effect against paracetamol (PCM) induced liver damage in rats. en_US
dc.publisher European Journal of Medicinal Plants en_US
dc.subject Holostemma ada kodien shcult; hepatoprotective activity; paracetamol; albino rats; histopathological studies en_US
dc.title Hepatoprotective Activity of Holostemma ada Kodien shcult, Extract against Paracetamol Induced Hepatic Damage in Rats en_US
dc.type Article en_US


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