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A new validated RP-HPLC method for determination of Rosuvastatin calcium in bulk and pharmaceutical dosage form

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dc.contributor.author Donthula, Sandhya
dc.contributor.author Kumar, Meriga Kiran
dc.contributor.author Teja, G. Shiva
dc.contributor.author Kumar, Mohan
dc.contributor.author Janapati, Yasodha Krishna
dc.date.accessioned 2020-01-03T12:43:28Z
dc.date.available 2020-01-03T12:43:28Z
dc.date.issued 2011
dc.identifier.uri http://erepo.usiu.ac.ke/11732/5162
dc.description Journal Article en_US
dc.description.abstract A simple, rapid, and precise RP-HPLC method for analysis of Rosuvastatin calcium in bulk and its pharmaceutical formulations has been developed and validated. The separation was achieved on Luna C18, 5μm 4.6 mm×250 mm column, using mobile phase composition of buffer (pH 4.5): Acetonitrile: methanol (45:25:35), at a flow rate of 1.0 ml/min at a detection wavelength of 248 nm. Rosuvastatin is eluted at retention time of 9.9 min. The method was validated for accuracy, precision, linearity, specificity and sensitivity in accordance with ICH guidelines. Validation revealed the method is specific, rapid, accurate, precise, reliable, and reproducible. Calibration plots were linear over the concentration ranges 25-75 μg mL−1. Limits of detection and limits of quantification were 3.5μgmL−1 and 10.5μg mL−1, respectively for both the drugs. The high recovery and low coefficients of variation confirm the suitability of the method for analysis of the rosuvastatin in formulations. en_US
dc.publisher Scholars Research Library en_US
dc.subject RP-HPLC, Rosuvastatin, Crestor en_US
dc.title A new validated RP-HPLC method for determination of Rosuvastatin calcium in bulk and pharmaceutical dosage form en_US
dc.type Article en_US


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