Iron Status and Associated Malaria Risk among African Children

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dc.contributor.author Muriuki, John M.
dc.contributor.author Mentzer, Alexander J.
dc.contributor.author Kimita, Wandia
dc.contributor.author Ndungu, Francis M.
dc.contributor.author Macharia, Alex W.
dc.contributor.author Webb, Emily
dc.contributor.author Lule, Swaib A.
dc.contributor.author Morovat, Alireza
dc.contributor.author Hill, Adrian V.
dc.contributor.author Bejon, Philip
dc.contributor.author Elliott, Alison M.
dc.contributor.author Williams, Thomas N.
dc.contributor.author Atkinson, Sarah H.
dc.date.accessioned 2019-02-07T09:23:23Z
dc.date.available 2019-02-07T09:23:23Z
dc.date.issued 2018
dc.identifier.uri http://erepo.usiu.ac.ke/11732/4320
dc.description Journal Article en_US
dc.description.abstract It remains unclear whether improving iron status increases malaria risk, and few studies have looked at the effect of host iron status on subsequent malaria infection. We therefore aimed to determine whether a child’s iron status influences their subsequent risk of malaria infection in sub-Saharan Africa. We assayed iron and inflammatory biomarkers from community-based cohorts of 1309 Kenyan and 1374 Ugandan children aged 0–7 years and conducted prospective surveillance for episodes of malaria. Poisson regression models were fitted to determine the effect of iron status on the incidence rate ratio (IRR) of malaria using longitudinal data covering a period of 6 months. Models were adjusted for age, sex, parasitemia, inflammation, and study site. At baseline, the prevalence of iron deficiency (ID) was 36.9% and 34.6% in Kenyan and Ugandan children, respectively. ID anemia (IDA) affected 23.6% of Kenyan and 17.6% of Ugandan children. Malaria risk was lower in children with ID (IRR, 0.7; 95% confidence interval [CI], 0.6, 0.8; P < .001) and IDA (IRR, 0.7; 95% CI, 0.6, 0.9; P = .006). Low transferrin saturation (<10%) was similarly associated with lower malaria risk (IRR, 0.8; 95% CI, 0.6, 0.9; P = .016). However, variation in hepcidin, soluble transferrin receptors (sTfR), and hemoglobin/anemia was not associated with altered malaria risk. ID appears to protect against malaria infection in African children when defined using ferritin and transferrin saturation, but not when defined by hepcidin, sTfR, or hemoglobin. Additional research is required to determine causality. en_US
dc.language.iso en en_US
dc.publisher Oxford University Press en_US
dc.relation.ispartofseries CID Vol. 67, 6, Sept 2018;
dc.subject Iron Status en_US
dc.subject Iron Deficiency en_US
dc.subject Malaria Risk en_US
dc.subject African Children en_US
dc.title Iron Status and Associated Malaria Risk among African Children en_US
dc.type Article en_US

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