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Infectious Diarrhoea in Antiretroviral Therapy-Naive HIV/AIDS Patients in Kenya

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dc.contributor.author Wanjiri, Jane W.
dc.contributor.author Kanyi, Henry
dc.contributor.author Maina, Samuel
dc.contributor.author Wang, David E.
dc.contributor.author Ngugi, Paul
dc.contributor.author O’Connor, Roberta
dc.contributor.author Kamau, Timothy
dc.contributor.author Waithera, Tabitha
dc.contributor.author Kimani, Gachuhi
dc.contributor.author Wamae, C.N.
dc.contributor.author Mwamburi, Mkaya
dc.contributor.author Ward, Honorine D.
dc.date.accessioned 2018-06-20T07:54:29Z
dc.date.available 2018-06-20T07:54:29Z
dc.date.issued 2013
dc.identifier.uri http://erepo.usiu.ac.ke/11732/3867
dc.description Journal Article en_US
dc.description.abstract Diarrhoea is a significant cause of morbidity and mortality in immunocompromised patients. The objectives of this study were to investigate the aetiological agents, risk factors and clinical features associated with diarrhoea in HIV/AIDS patients in Kenya. Sociodemographic, epidemiological and clinical datawere obtained for 164 HIV/AIDS patients (70 with and 94 without diarrhoea) recruited from Kenyatta National Hospital, Kenya. Stool samples were examined for enteric pathogens by microscopy and bacteriology. Intestinal protozoa and fungi were identified in 70% of patients, more frequently in those with diarrhea (p,0.001). Helminths were detected in 25.6% of patients overall, and bacterial pathogens were identified= in 51% of patients with diarrhoea. Polyparasitism was more common in patients with diarrhoea than those without (p,0.0001). Higher CD4+ T-cell count (OR ¼ 0.995, 95% CI 0.992–0.998) and water treatment (OR ¼ 0.231, 95% CI 0.126–0.830) were associated with a lower risk of diarrhoea, while close contact with cows (OR ¼ 3.200, 95% CI 1.26–8.13) or pigs (OR ¼ 11.176, 95% CI 3.76–43.56) were associated with a higher risk of diarrhoea. Multiple enteric pathogens that are causative agents of diarrhoea were isolated from stools of antiretroviral therapy-naive HIV/AIDS patients, indicating a need for surveillance, treatment and promotion of hygienic practices. en_US
dc.language.iso en en_US
dc.publisher Oxford University Press en_US
dc.relation.ispartofseries Trans R Soc Trop Med Hyg 2013; 107: 631–638;
dc.subject HIV/AIDS en_US
dc.subject Diarrhoea en_US
dc.subject Enteric pathogens en_US
dc.subject Isospora en_US
dc.subject Cryptosporidium en_US
dc.subject Shigella en_US
dc.title Infectious Diarrhoea in Antiretroviral Therapy-Naive HIV/AIDS Patients in Kenya en_US
dc.type Article en_US


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