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Immuno–Parasitological Assessment of Bancroftian Filariasis in a Highly Endemic Area along the River Sabaki, In Malindi District, Kenya

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dc.contributor.author Njenga, S.M.
dc.contributor.author Wamae, C.N.
dc.contributor.author Mwandawiro, C.S.
dc.contributor.author Molyneux, D.H.
dc.date.accessioned 2018-05-11T09:35:34Z
dc.date.available 2018-05-11T09:35:34Z
dc.date.issued 2007
dc.identifier.uri http://erepo.usiu.ac.ke/11732/3828
dc.description Article Journal en_US
dc.description.abstract Lymphatic filariasis is endemic in the coastal areas of Kenya, with four major foci identified in the early 1970s. The prevalence and intensity of Wuchereria bancrofti infection, together with antifilarial antibody responses, were assessed in a historically highly endemic focus along the River Sabaki, in Malindi district. The prevalences of microfilaraemia and antigenaemia (detected by Og4C3 ELISA) were .20% and .40%, respectively, and both increased steadily with age. The high prevalences of antifilarial IgG1 (86%) and IgG4 (91%) responses indicate that most people living in this setting are exposed to W. bancrofti infection. The children investigated had higher levels of antifilarial IgG1 than the adults.The results of this study, based on a battery of currently available parasitological and immunological methods, provide an epidemiological update on lymphatic filariasis on the northern Kenyan coast. They show that the River Sabaki area is still an important focus for bancroftian filariasis and highlight the importance of implementing an elimination programme, to interrupt the transmission of W. bancrofti in all areas of endemicity in Kenya. The detailed baseline data collected in the River Sabaki area make the communities studied ideal as sentinel sites for epidemiological monitoring and the evaluation of the impact of mass drug administrations to eliminate lymphatic filariasis. en_US
dc.language.iso en en_US
dc.publisher The Liverpool School of Tropical Medicine en_US
dc.relation.ispartofseries Annals of Tropical Medicine & Parasitology, Vol. 101, No. 2, 161–172 (2007);
dc.subject Immuno–Parasitological en_US
dc.subject Bancroftian Filariasis en_US
dc.subject Highly Endemic Area en_US
dc.subject River Sabaki en_US
dc.subject Malindi District en_US
dc.title Immuno–Parasitological Assessment of Bancroftian Filariasis in a Highly Endemic Area along the River Sabaki, In Malindi District, Kenya en_US
dc.type Article en_US


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