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Evaluation of Effectiveness of Diethylcarbamazine/Albendazole Combination in Reduction of Wuchereria Bancrofti Infection using Multiple Infection Parameters

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dc.contributor.author Wamae, C.N.
dc.contributor.author Njenga, S.M.
dc.contributor.author Ngugi, B.M.
dc.contributor.author Mbui, J.
dc.contributor.author Njaanake, H.K
dc.date.accessioned 2018-05-11T09:16:28Z
dc.date.available 2018-05-11T09:16:28Z
dc.date.issued 2010
dc.identifier.uri http://erepo.usiu.ac.ke/11732/3826
dc.description Article Journal en_US
dc.description.abstract To evaluate the effect of multiple rounds of annual single dose of DEC (6 mg/kg) or albendazole (400 mg) given alone or in combination on Wuchereria bancrofti microfilaraemia, anti-filarial IgG1 and IgG4 and antigenaemia. A total of 170 participants were randomly assigned to albendazole (n = 62), DEC (n = 54), and DEC plus albendazole (DEC/ALB) combination (n = 54). Blood samples were collected at pre-treatment in 1998, at 1 week and 6 months after the first treatment and thereafter before subsequent treatments in 1999 and 2000. Effects of treatment on W. bancrofti infection were determined by changes in levels of microfilaraemia, antifilarial antibodies and circulating filarial antigen. Comparison of geometric mean microfilariae intensities between DEC/ALB combination and DEC or albendazole single therapy groups after two rounds of annual treatment and 24 months follow-up showed that combination therapy resulted in a greater reduction of microfilaraemia than single therapy with either albendazole (p < 0.001) or DEC alone (p = 0.146). The overall levels of anti-filarial antibodies decreased significantly (p = 0.028 for IgG1 and p < 0.043 for IgG4) in all treatment groups at 24 months follow-up. Additionally, overall reduction in geometric mean circulating filarial antigen levels at 24 months was 44%, 60% and 85% for albendazole, DEC and DEC/ALB groups, respectively.These study findings suggest that albendazole improved efficacy of DEC and mass administration of a combination of the two drugs would therefore enhance the interruption of transmission of W. bancrofti in endemic areas. This information has important implications for the ongoing Global Program for Elimination of Lymphatic Filariasis. en_US
dc.language.iso en en_US
dc.publisher Elsevier Science Ltd. en_US
dc.relation.ispartofseries Acta Tropica 120S (2011) S33– S38;
dc.subject Diethylcarbamazine/Albendazole en_US
dc.subject Wuchereria bancrofti en_US
dc.subject Infection en_US
dc.subject Infection Parameters en_US
dc.title Evaluation of Effectiveness of Diethylcarbamazine/Albendazole Combination in Reduction of Wuchereria Bancrofti Infection using Multiple Infection Parameters en_US
dc.type Article en_US


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