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Biochemical changes in cerebrospinal fluid of Chlorocebus aethiops naturally infected with zoonotic Meningonema peruzzii

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dc.contributor.author Ngure, R.M.
dc.contributor.author Karanja, S.M.
dc.contributor.author Mungatana, N.K.
dc.contributor.author Wamae, C.N.
dc.contributor.author Ngotho, J.M.
dc.contributor.author Gichuki, C.W.
dc.date.accessioned 2018-05-11T09:03:58Z
dc.date.available 2018-05-11T09:03:58Z
dc.date.issued 2007
dc.identifier.uri http://erepo.usiu.ac.ke/11732/3825
dc.description Journal Article en_US
dc.description.abstract Thirty-four wild Chlorocebus aethiops monkeys were trapped for research purposes. During routine quarantine check-up, cerebrospinal fluid (CSF) and blood were microscopically examined for parasites. Estimations of CSF protein levels were made by the biuret method and the white cell counts by the hemocytometer. Seven monkeys demonstrated microfilariae in blood and CSF. This was accompanied by a two- and ninefold increase in CSF total protein and white cell counts, respectively. Necropsy of one of the blood and CSF microfilariae-positive animals revealed the presence of adult worms in the brain meninges. The parasites were identified as the zoonotic filaroid nematode Meningonema peruzii. Wild C. aethiops monkeys developed CSF changes resulting, most probably, from infection with M. peruzii. Moreover, the monkeys could be acting as an important reservoir. The study highlights the need for epidemiological and pathogenological studies of this parasite, which is of public health significance. Moreover, C. aethiops proved to be a useful primate model for the study of this zoonotic infection. en_US
dc.language.iso en en_US
dc.publisher Blackwell Munksgaard en_US
dc.relation.ispartofseries Med Primatol doi:10.1111/j.1600-0684.2008.00282.x;
dc.subject Total Protein en_US
dc.subject White Cell Counts en_US
dc.subject Zoonosis en_US
dc.title Biochemical changes in cerebrospinal fluid of Chlorocebus aethiops naturally infected with zoonotic Meningonema peruzzii en_US
dc.type Article en_US


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